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Recall of GSK's Augmentin tablet ordered due to plasticizer contamination

Updated: 2011-07-19 18:24

By Shan Juan (chinadaily.com.cn)

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The Department of Health (DH) of Hong Kong ordered Tuesday GlaxoSmithKline Limited (GSK) to recall from shelf an antibiotic, namely Augmentin 375mg tablet (HK-47298), because samples of the product were found to contain plasticisers, including diisodecyl phthalate (DIDP), di(2-ethylhexyl) phthalate (DEHP) and diisononyl phthalate (DINP).

A spokesman for DH said, "Following the recall of GSK's Augmentin powder for syrup, the DH has conducted the enhanced surveillance. During the surveillance, the Government Laboratory (GL) found that samples of Augmentin 375mg tablet contained detectable level of plasticisers, which raised quality concerns. According to the GL analysis, up to 2.7ppm of DIDP, 1.1ppm of DEHP and 3.5ppm of DINP were found in samples of the product. Further tests have been conducted but the sources of the plasticisers are yet to be determined. Since GSK could not provide satisfactory explanation on sources of the plasticisers, the quality of the product is in question."

DH investigation continues.

"The levels of plasticisers are considered unlikely to cause acute harmful effects if taken according to the recommended dosage. DH will seek Department of Justice's advice on possible legal actions against GSK," the spokesman said.

"Augmentin 375mg tablet is an antibiotic for the treatment of bacterial infections. Patients who are currently using the drug for treatment should consult their attending doctors or pharmacists as soon as possible and should not just stop using the drug by themselves," the spokesman warned, "otherwise, there could be implications on both the courses of the diseases under treatment as well as antibiotic resistance development here."

In connection, anyone who has taken the drug and is either in doubt or feeling unwell ought to seek professional advice from healthcare providers.

In mid June, China's top drug authority ordered the recall of Augmentin Syrup manufactured by GSK, due to detected contamination of a banned plasticizer, according to the State Food and Drug Administration. No adverse reactions related to its use have been reported on the mainland so far.

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