www射-国产免费一级-欧美福利-亚洲成人福利-成人一区在线观看-亚州成人

USEUROPEAFRICAASIA 中文雙語Fran?ais
China
Home / China / Society

Study: Infertile males can blame gene mutations

By Zhou Wenting in Shanghai | China Daily | Updated: 2017-06-06 07:11

Scientists in Shanghai have discovered that a mutation at a specific location in a gene - mainly active in male reproductive cells - leads to male infertility. And they've figured out how it works, which is likely to bring new insights into treatment.

The scientists discovered that infertility results when a key step in the development of sperm cells is obstructed by the mutation at a domain called "D-box" on the gene Hiwi. Their findings were published recently on the website of the scientific journal Cell, which is based in the United States.

Before a sperm cell matures, the histones in genomic DNA must transform into another form automatically, so that the genetic materials from the male are stored in the sperm head in a safer and more condensed way, explained Liu Mofang, the lead researcher on the team at the Institute of Biochemistry and Cell Biology, a branch of the Chinese Academy of Sciences' Shanghai Institutes for Biological Sciences.

"But the mutation hindered the transformation from taking place during the late stages of sperm formation, which results in a drastic decrease in the number of sperm, abnormal structure of the sperm head and sperm viability loss," Liu said.

There are many types of gene mutations that appear to correlate with human male infertility. However, only a handful of such mutations have been scientifically proved to result in infertility, Liu said.

In their lab experiments, the researchers successfully overrode the obstruction by inserting a certain part of a protein into the sperm cell of mice with the mutation.

"The sperm will thus restore normal structure and activity," Liu said.

According to one scientific reviewer of the research, "The observation of human Hiwi mutations in azoospermia is extremely exciting and provides a clear context for disease relevance".

Wang Jian, deputy director of the Shanghai Institute of Planned Parenthood Research, said it's widely acknowledged in medical circles that problems in males are a factor in half the infertility cases around the world.

"A low number of sperm, low activity of sperm and malformation of sperm are important reasons that cause male infertility, but the strategies for diagnosis and treatment are quite limited so far," Wang said. "This discovery will provide a potential solution for certain types of human male infertility."

Liu said the mutation is either acquired from the male subject's mother or happens for unknown reasons before he is born.

"If a mother carries the mutation, she is able to give birth, because the mutation doesn't affect women's fertility. But if she gives birth to a boy, he stands a 50-percent chance of inheriting the mutation from his mother," she said.

A test for the mutation could be included in voluntary premarital health checks through blood testing in the future, Liu said.

Editor's picks
Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
 
主站蜘蛛池模板: 亚洲第一免费网站 | 毛片免费观看久久欧美 | 私人玩物福利视频 | 看真人一一级毛片 | 伊人色在线观看 | 高清在线亚洲精品国产二区 | 亚洲国产一区二区三区在线观看 | 国产亚洲精品久久久久久无 | 国产亚洲精品自在久久77 | 99视频只有精品 | 亚洲欧洲日韩综合色天使不卡 | 国产一级爱做片免费观看 | 亚洲国产高清视频在线观看 | 第一色区| 亚洲成aⅴ人片在线影院八 亚洲成av人片在线观看 | 日本精品中文字幕有码 | 丝袜美腿精品一区二区三 | 亚洲一区视频在线 | 亚洲视频二 | 成人免费手机在线看网站 | 国产日韩欧美网站 | 欧美一欧美一级毛片 | 韩国日本一级毛片免费视频 | 欧美日韩精品一区二区视频在线观看 | 中文字幕在线不卡 | 三级大片网站 | 亚洲精品综合一区二区三区 | 成人18免费软件 | 白白在线观看永久免费视频 | 日韩毛片 | 中国一级大黄大片 | 欧美顶级毛片在线播放 | 欧美精品综合一区二区三区 | 狠狠色综合久久丁香婷婷 | 国产成人久久精品二区三区 | 欧美特黄一级片 | 国产二区三区 | 456亚洲老头视频 | 亚洲午夜久久久久影院 | 女高中生被cao到哭视频 | 成人午夜影视全部免费看 |