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Two Australians win Nobel Prize in medicine
(AP)
Updated: 2005-10-03 21:00


Australian Robin Warren seen at a presentation dinner in Adelaide, South Australia in 1998. Warren and fellow Australian doctor Barry J Marshall have won the 2005 Nobel Prize in medicine, it was announced in Stockholm Monday Oct 3 2005. Their award was for discovering that bacteria, not stress, was the main cause of painful ulcers of the stomach and intestine. [AP]

Warren said he was "very excited also a little overcome," at the honor.

"The idea of stress and things like that (causing ulcers) was just so entrenched nobody could really believe that it was bacteria," Marshall said. "It had to come from some weird place like Perth, Western Australia, because I think nobody else would have even considered it."

The discovery has stimulated research into microbes as possible reasons for other chronic inflammatory conditions, such as Crohn's disease, ulcerative colitis, rheumatoid arthritis and atherosclerosis, the assembly said in its citation.

Warren, a pathologist from Perth, Australia, "observed small curved bacteria colonizing the lower part of the stomach in about 50 percent of patients from which biopsies had been taken," the Nobel Assembly said. "He made the crucial observation that signs of inflammation were always present ... close to where the bacteria were seen."

Marshall became interested in Warren's findings and together they initiated a study of biopsies from 100 patients.

"After several attempts, Marshall succeeded in cultivating a hitherto unknown bacterial species — later denoted Helicobacter pylori — from several of these biopsies," the assembly said. "Together they found that the organism was present in almost all patients with gastric inflammation, duodenal ulcer or gastric ulcer."
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