www射-国产免费一级-欧美福利-亚洲成人福利-成人一区在线观看-亚州成人

Global EditionASIA 中文雙語Fran?ais
World
Home / World / China-Europe

Mutation discovery could help prevent genetic disorders

By Angus McNeice in London | chinadaily.com.cn | Updated: 2018-01-11 01:58
Share
Share - WeChat

Scientists from Britain and China have made a discovery that might lead to the ability to repair mutations in genes that cause harmful disorders, such as cystic fibrosis and certain cancers.

Geneticists at the United Kingdom's Oxford University and Zhejiang University in China have discovered that cells rank genes by importance, and give certain regions of our genetic make-up special treatment when repairing mutations.

Genetic mutations are one of the driving forces of evolution. They happen when a cell makes an error while copying DNA – the molecules that make up our genes. Some mutations cause no harm or even end up being beneficial, but others are responsible for illnesses such as muscular dystrophy and types of cancer.

Nicholas Harberd, a plant geneticist at Oxford University and lead author of the study, said his research suggests cells have found a way to target "important" regions of genetic material for protection against mutation, and that they focus less attention on other regions.

The study, published in the journal Genome Research, looks at a mechanism called DNA mismatch repair, or MMR, in plant cells.

During the MMR process, which occurs in cells throughout the animal and plant kingdom, an enzyme repairs parts of DNA that have been copied incorrectly during cell replication.

The scientists compared the frequency and distribution of mutations in the genome of plants that were proficient in MMR against those in a plant strain that was not able to perform MMR.

The genome is the sum of the genetic material in a cell. A minority of an organism's genome is made up of genes which code for proteins – large regions of the genome are made up of "non-coding" DNA.

The researchers found that in the MMR-deficient strain, mutations were more regular and were randomly distributed throughout the genome.

In the MMR-proficient plant genome, mutations were less regular and were not as randomly distributed. Areas of the genome that code for genes had fewer mutations than areas of the genome that do not code for genes.

"It suggests that our cells and the cells of living organisms have developed the ability to target their protection particularly to genes, rather than non-gene parts of the genome," Harberd said.

Harberd said the discovery could provide valuable information to scientists who are developing ways to eliminate harmful mutations in the human genome. Other gene editing processes found in nature – such as CRISPR – have led to technology that can alter the genome with incredible accuracy.

"From a scientific perspective, that's probably quite reasonable," Harberd said. "But that's very much in the long term, and that whole issue is fraught with ethical and legislative concerns. What's exciting is that we've come to understand more about evolution and variation. Mutation is often described as being a random process – I guess what we are suggesting is that it's somewhat less random that previously people had realized."

Most Viewed in 24 Hours
Top
BACK TO THE TOP
English
Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
主站蜘蛛池模板: 麻豆日韩 | 国产在线成人精品 | 亚洲国产成人久久三区 | 欧美成人三级伦在线观看 | 亚洲欧美成人影院 | 欧美久 | 亚洲一区免费在线观看 | 国产男女视频 | 美女张腿男人桶免费视频 | 亚洲国产一区二区三区a毛片 | 九九视频在线观看 | 99精品久久久久久久免费看蜜月 | 久久免费精品 | 一级爱做片免费观看久久 | 天天综合天天看夜夜添狠狠玩 | 日韩一级a毛片欧美区 | 精品一区二区三区在线视频 | 看免费人成va视频全 | www.色片| 亚洲欧美精品网站在线观看 | 一级一片一a一片 | 午夜丝袜美腿福利视频在线看 | 精品久久久久久久久中文字幕 | 怡红院免费va男人的天堂 | 亚洲第一页在线视频 | 一区二区三区 亚洲区 | 九九99久麻豆精品视传媒 | 欧美精品免费线视频观看视频 | 欧美日韩一区二区三区视频播 | 亚洲福利影视 | 一级中国毛片 | 久久免费播放视频 | 国产一级毛片午夜 | 亚洲免费在线视频观看 | 亚洲高清中文字幕一区二区三区 | 国产精品一区在线观看 | 萌白酱粉嫩jk福利视频在线观看 | 免费aⅴ片 | 久久爱青青草 | 亚洲日本中文字幕在线 | 在线欧美精品二区三区 |