www射-国产免费一级-欧美福利-亚洲成人福利-成人一区在线观看-亚州成人

USEUROPEAFRICAASIA 中文雙語(yǔ)Fran?ais
China
Home / China / Innovation

Chinese scientists give big boost to cancer-killing virus

Xinhua | Updated: 2017-08-24 14:41

Chinese scientists have found a compound that helped a tumor-targeting virus kill liver cancer more effectively while sparing healthy cells, offering new hope for treating the world's second most common cancer killer, according to a study published Wednesday.

A therapy using viruses that selectively kill cancer cells, dubbed oncolytic viruses, is rapidly progressing through clinical evaluation, but the therapeutic efficacy in humans has been less than expected from preclinical studies, according to the study published in the U.S. journal Science Translational Medicine.

Oncolytic virotherapy involving M1 virus, a mosquito-borne pathogen that predominantly causes mild illness in horses, is believed to be a potentially attractive strategy for the treatment of hepatocellular carcinoma (HCC), the most common type of liver cancer.

In order to boost the virus's antitumor effects, Professor Guangmei Yan of Sun Yat-sen University in China and colleagues screened 350 small molecules to identify compounds that can enhance viral killing of cultured HCC cells.

The researchers found that Eeyarestatin I, an inhibitor of the protein VCP, which has been linked to causing malignancy, as the strongest sensitizer for M1 virus, as it increased the potency of the virus by as much as 3,600-fold against the HCC cells.

The dual regimen had no effect on non-cancerous cells, they said.

In multiple mouse models of HCC, M1 together with Eeyarestatin I were found to shrink tumors and significantly prolong survival.

The researchers further demonstrated that the duo was safe and well-tolerated in monkeys.

"We can describe the M1 oncolytic virus as a guided missile that automatically targets tumor cells, and the addition of the VCP inhibitor is just like binding the missile to powerful explosives with the ability of auto-selection," Yan explained to Xinhua.

"The outcome is self-evident with such a strong combination," he said.

Yan said they plan to submit a clinical trial application for the combination therapy strategy in 2018.

"Hepatocellular carcinoma is the second leading cause of cancer-related death in men and claims more than 700,000 lives per year worldwide," their paper wrote. "Our study identifies combined VCP inhibition and oncolytic virus as a potential treatment for HCC and demonstrates promising therapeutic potential."

Editor's picks
Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
 
主站蜘蛛池模板: 久久国产精品一区二区三区 | 日本阿v视频在线观看高清 日本波多野结衣视频 | 一级毛片免费观看不卡的 | 欧美成人综合 | se视频在线观看 | 亚洲精品美女在线观看 | 波多野结衣在线观看高清免费资源 | 欧美日韩一区二区综合在线视频 | 国产免费人成在线看视频 | 久久久香蕉视频 | 日韩美视频网站 | 国产日产欧产精品精品推荐小说 | 亚洲一区二区三区成人 | 韩国三级日本三级香港三级黄 | 久草com| 在线观看免费视频网站色 | 亚洲国产成人久久综合野外 | 2022国产精品手机在线观看 | 孕妇孕妇aaaaa级毛片视频 | 91精品国产综合久久久久久 | 九九99久麻豆精品视传媒 | 久久亚洲国产中v天仙www | 美女被男人桶到嗷嗷叫爽网站 | 亚洲欧美成人影院 | 九一精品| 在线免费视频国产 | 在线天天干 | 亚洲国产成人在线观看 | 午夜伦4480yy妇女久久久 | 日韩欧美成末人一区二区三区 | 久草在线免费资源 | 亚洲国产高清视频在线观看 | www.av在线.com| 三级网站在线 | 久草在线首页 | 国产亚洲精品自在线观看 | 精品a视频 | 欧美精品区 | 一区二区三区精品国产欧美 | 综合中文字幕 | 国产aⅴ精品一区二区三区久久 |